Clinical Studies

Randomized trial in 204 patients concludes that the treatment of de novo lesions with the GENIE after bare metal stenting (BMS) is safe; the results in terms of clinical events and restenosis are better than BMS alone and equivalent to a drug-eluting stent (TAXUS). Download article
Animal study on 30 pigs shows that local delivery of Paclitaxel via the GENIE is safe and effective to significantly reduce the proliferative response post-stent implantation or balloon dilatation. Download article
Only few minutes exposure to Paclitaxel is sufficient to have a long-lasting antiproliferative effect on human arterial smooth muscle cell.Download article
Other Publications
- Local Paclitaxel Delivery for the Prevention of Restenosis: biological effects and efficacy in vivo, Herdeg et all., JACC 2000” Download article
- “Addition of Paclitaxel to Contrast Media Prevents Restenosis after Coronary Stent Implantation, Scheller et all., JACC 2003” Download article
- “Successful local antiproliferative paclitaxel delivery in a repeatedly restenosed lesion of the right coronary artery after drug eluting-stent implantation, Herdeg et all., Clin Res. Cardiol 2008”.Download article